Related Experiment Video
Updated: Jul 18, 2026
11:04
An In-House-Built and Light-Emitting-Diode-Based Photodynamic Therapy Device for Enhancing Verteporfin Cytotoxicity in a 2D Cell Culture Model
Published on: January 13, 2023
Introduction to photodynamic therapy: early experience
1Gold Skin Care Center, Tennessee Clinical Research Center, 200 Richard Jones Road, Suite 200, Nashville, TN 37215, USA. goldskin@goldskincare.com
Dermatologic Clinics
|November 28, 2006
Summary
Photodynamic therapy (PDT) is a revolutionary dermatologic treatment with a history dating back to the early 1900s. This therapy utilizes photosensitizers to treat various skin conditions effectively.
Area of Science:
- Dermatology
- Photochemistry
- Oncology
Background:
- Photodynamic therapy (PDT) has evolved significantly since its early 1900s origins.
- The development of topical photosensitizers, notably by Kennedy et al. in 1990, marked a pivotal advancement.
- PDT is increasingly integrated into standard dermatologic surgical practices worldwide.
Purpose of the Study:
- To provide a historical overview of photodynamic therapy.
- To review currently available topical photosensitizers and their applications in dermatology.
- To highlight the expanding role and new applications of PDT in dermatologic surgery.
Main Methods:
- Historical review of photodynamic therapy.
- Summary of key advancements, including the discovery of topical photosensitizers.
- Analysis of the clinical applications and efficacy of commercially available PDT agents.
Main Results:
- PDT's history spans over a century, with significant progress in recent decades.
- Two main topical photosensitizers are commercially available, each with specific dermatologic uses.
- PDT is a versatile therapeutic modality with established and emerging applications.
Conclusions:
- Photodynamic therapy is a valuable and evolving treatment option in dermatologic surgery.
- The ongoing research and development in PDT continue to expand its clinical utility.
- PDT offers effective treatment for various skin conditions, with new niches continually being discovered.
