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Updated: Jul 18, 2026
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An In Vitro Approach to Photodynamic Therapy
Published on: August 17, 2018
Photodynamic therapy for actinic keratoses
1Division of Dermatology and Cutaneous Sciences, University of Alberta, 2-125 Clinical Sciences Building, Edmonton, Alberta T6G 2G3, Canada.
Dermatologic Clinics
|November 28, 2006
Summary
Photodynamic therapy (PDT) is an effective treatment for actinic keratoses (AKs), precancerous skin lesions. This review details PDT
Area of Science:
- Dermatology
- Oncology
- Photomedicine
Background:
- Actinic keratoses (AKs) are common premalignant skin lesions with potential to progress to squamous cell carcinoma.
- Early detection and treatment of AKs are crucial for preventing invasive cancer.
- Photodynamic therapy (PDT) offers a versatile therapeutic option for AK management.
Purpose of the Study:
- To provide a practical overview of photodynamic therapy (PDT) for treating actinic keratoses (AKs).
- To review clinical trial outcomes and special applications of PDT in high-risk populations.
- To offer step-by-step guidance on conducting PDT sessions for AK treatment.
Main Methods:
- Review of clinical trials and literature on photodynamic therapy for actinic keratoses.
- Focus on practical aspects including photosensitizers (aminolevulinic acid, methyl aminolevulinate) and light sources.
- Inclusion of step-by-step procedural descriptions for PDT sessions.
Main Results:
- Photodynamic therapy (PDT) demonstrates efficacy in treating actinic keratoses (AKs).
- Various photosensitizers and light sources are available for PDT.
- PDT is applicable in special populations, including transplant recipients.
- Clinical trial data support the use of PDT for AKs.
Conclusions:
- Photodynamic therapy (PDT) is a valuable and versatile treatment modality for actinic keratoses (AKs).
- Understanding practical aspects and outcomes is essential for optimizing PDT efficacy.
- PDT offers a targeted approach for managing AKs, particularly in immunocompromised individuals.
