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Antioxidants decrease reperfusion induced arrhythmias in myocardial infarction with ST-elevation.

Juan J Hicks1, Daniel H Montes-Cortes, Maria P Cruz-Dominguez

  • 1Laboratorio de Bioquimica Inorganica, Departamento de Investigacion en Bioquímica y Medicina Ambiental, Instituto Nacional de Enfermedades Respiratorias, DF Mexico. jhicks@iner.gob.mx

Frontiers in Bioscience : a Journal and Virtual Library
|November 28, 2006
PubMed
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Antioxidant vitamins significantly reduced arrhythmias and biochemical damage caused by reperfusion injury following heart attacks treated with thrombolysis. This suggests antioxidants may help manage reperfusion-induced arrhythmias.

Area of Science:

  • Cardiology
  • Biochemistry
  • Pharmacology

Background:

  • ST-segment elevation myocardial infarction involves ischemia-reperfusion (IR) injury.
  • Reactive oxygen species (ROS) contribute to IR-induced arrhythmias and endothelial dysfunction.
  • Therapeutic thrombolysis (alteplase) is used to treat myocardial infarctions.

Purpose of the Study:

  • To investigate the impact of antioxidant vitamins on biochemical changes and arrhythmias.
  • To assess the effect of antioxidants before and after therapeutic thrombolysis.
  • To determine if antioxidants can mitigate reperfusion injury.

Main Methods:

  • A study involving patients undergoing thrombolysis for myocardial infarction.
  • Administration of antioxidant vitamins versus placebo.

Related Experiment Videos

  • Measurement of arrhythmias, plasma malondialdehyde, circulating neutrophils, plasma antioxidant capacity, and paraoxonase-1 levels.

    • Main Results:

    • Antioxidant group showed significant reductions in premature ventricular beats, atrial fibrillation, ventricular tachycardia, and AV block compared to placebo.
    • Plasma malondialdehyde and circulating neutrophils were significantly lower in the antioxidant group.
    • Plasma antioxidant capacity and paraoxonase-1 levels were significantly increased in the antioxidant group.

    Conclusions:

    • Antioxidant vitamins may be beneficial as adjunctive therapy for controlling reperfusion-induced arrhythmias.
    • Antioxidants appear to reduce biochemical markers of oxidative stress and inflammation post-thrombolysis.
    • Further research is warranted to confirm the role of antioxidants in managing IR injury.