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14:10
Characterizing Salmonella Typhimurium-induced Septic Peritonitis in Mice
Published on: July 29, 2022
Rare serotype non-typhoidal Salmonella sepsis
V S Randhawa1, Geeta Mehta, Anupam Das
1Department of Microbiology, Lady Hardinge Medical College and associated Kalawati Saran Children, Hospital, New Delhi, India. vsrandh@yahoo.com
Indian Journal of Pediatrics
|November 28, 2006
Summary
This case report details the first instance of Salmonella Virchow bacteremia in India, identified in an 11-month-old infant with persistent diarrhea and sepsis. The pathogen was susceptible to most antibiotics, highlighting a potential treatment challenge.
Area of Science:
- Pediatric Infectious Diseases
- Microbiology
- Bacteriology
Background:
- Non-typhoidal Salmonellae (NTS) are significant causes of bloodstream infections globally.
- Salmonella Virchow is a recognized NTS serotype causing bacteremia, particularly in Western countries.
- Limited data exists on S. Virchow infections in developing nations, especially in pediatric populations.
Observation:
- An 11-month-old infant presented with prolonged fever and diarrhea, unresponsive to initial antimicrobial therapy.
- The infant was diagnosed with persistent diarrhea, Protein-Energy Malnutrition (PEM) grade III, and sepsis.
- Blood culture isolated Salmonella Virchow, while stool cultures were negative for pathogens.
Findings:
- The isolated Salmonella Virchow strain demonstrated susceptibility to multiple common antimicrobial agents.
- Trimethoprim-Sulfamethoxazole was noted as an exception to the susceptibility profile.
- This case represents the first documented instance of Salmonella Virchow bacteremia in India.
Implications:
- This finding expands the known geographical distribution of Salmonella Virchow-related bacteremia.
- It underscores the importance of considering less common Salmonella serotypes in pediatric sepsis, even with negative stool cultures.
- Further surveillance and antimicrobial susceptibility studies are warranted for NTS in India.
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