Related Experiment Video
Updated: Jul 18, 2026
07:21
Processing of Bronchoalveolar Lavage Fluid and Matched Blood for Alveolar Macrophage and CD4+ T-cell Immunophenotyping and HIV Reservoir Assessment
Published on: June 23, 2019
[Pulmonary MALT lymphoma revealing AIDS]
A B Cortot1, V Cottin, B Issartel
1Service de Pneumologie, Centre de référence des Maladies Orphelines Pulmonaires, Hôpital Louis Pradel, Université de Lyon - UMR 754, Lyon, France.
Revue Des Maladies Respiratoires
|November 28, 2006
Summary
A rare case of pulmonary mucosa-associated lymphoid tissue (MALT) lymphoma revealed acquired immune deficiency syndrome (AIDS) in a patient. Combination therapy with rituximab and antiretrovirals achieved complete remission.
Area of Science:
- Oncology
- Infectious Diseases
- Immunology
Background:
- Mucosa-associated lymphoid tissue (MALT) lymphoma is a rare B-cell malignancy.
- Acquired immune deficiency syndrome (AIDS) is a chronic condition caused by the human immunodeficiency virus (HIV).
- This case highlights the potential for pulmonary MALT lymphoma to be an initial manifestation of AIDS.
Observation:
- A 30-year-old man presented with respiratory symptoms and was diagnosed with HIV infection.
- Thoracic CT revealed diffuse ground glass opacities and consolidation.
- Lung biopsy confirmed a low-grade B-cell MALT lymphoma (CD20+) with t(11;18) translocation.
Findings:
- The patient had an isolated pulmonary MALT lymphoma.
- No extrathoracic lymphoma was detected.
- Treatment with rituximab and highly active antiretroviral therapy (HAART) resulted in rapid and complete remission.
Implications:
- Pulmonary MALT lymphoma can be an indicator of underlying HIV infection and AIDS.
- Combined immunochemotherapy and antiretroviral treatment can be effective in managing this condition.
- This case underscores the importance of considering opportunistic infections and malignancies in patients with atypical presentations.
Related Concept Videos
01:27Cryptococcal Meningitis
Cryptococcal meningitis is a life-threatening opportunistic infection predominantly associated with HIV/AIDS, accounting for over 100,000 deaths annually worldwide. However, it also affects individuals with other forms of immunosuppression, including those undergoing immunosuppressive therapy, organ transplant recipients, patients with innate immunodeficiencies, and individuals with hematological disorders. The infection is caused mainly by Cryptococcus neoformans and Cryptococcus gattii,...
01:26Pulmonary Tuberculosis IV
Tuberculosis, more commonly referred to as TB, is an infectious disease stemming from Mycobacterium tuberculosis. While it primarily impacts the lungs, TB can also affect other body areas. Given its severity and global impact, timely and accurate diagnosis is crucial for controlling its spread and improving patient outcomes.
Several diagnostic approaches are used to detect TB. The conventional method is the Tuberculin Skin Test (TST), also known as the Mantoux test. However, this method has...
Several diagnostic approaches are used to detect TB. The conventional method is the Tuberculin Skin Test (TST), also known as the Mantoux test. However, this method has...
01:29Pulmonary Tuberculosis I
Tuberculosis, often called TB, is a contagious illness primarily caused by Mycobacterium tuberculosis. It mainly affects the lung parenchyma but can also impact other body parts.
Causative Organism
The primary infectious agent causing tuberculosis is Mycobacterium tuberculosis, a slow-growing, acid-fast, aerobic rod that exhibits sensitivity to heat and ultraviolet light. Instances of Mycobacterium bovis and Mycobacterium avium contributing to the development of TB infection are rare.
Mode of...
Causative Organism
The primary infectious agent causing tuberculosis is Mycobacterium tuberculosis, a slow-growing, acid-fast, aerobic rod that exhibits sensitivity to heat and ultraviolet light. Instances of Mycobacterium bovis and Mycobacterium avium contributing to the development of TB infection are rare.
Mode of...
01:28Pulmonary Tuberculosis II
Tuberculosis, or TB, is a bacterial infectious disease caused by Mycobacterium tuberculosis. While its primary impact is on the lungs, leading to pulmonary tuberculosis, it can also affect various other organs, a condition referred to as extrapulmonary tuberculosis.
Here is a detailed explanation of its pathophysiology:
Transmission: The process begins when a person inhales droplet nuclei containing M. tuberculosis. These are typically released into the air when an individual with pulmonary or...
Here is a detailed explanation of its pathophysiology:
Transmission: The process begins when a person inhales droplet nuclei containing M. tuberculosis. These are typically released into the air when an individual with pulmonary or...
01:31Pulmonary Tuberculosis III
Tuberculosis (TB) is a contagious infection primarily affecting the lung parenchyma but which can also affect other body parts. TB can be classified based on disease development, presentation, and the affected anatomical site.
The first classification is based on the development of the disease, and it includes the following categories:
The first classification is based on the development of the disease, and it includes the following categories:
01:28Pulmonary Tuberculosis V
Medical management of tuberculosis (TB) patients involves a comprehensive approach that includes diagnosis, treatment, and monitoring. The specific strategies can vary depending on the type of tuberculosis (latent or active), the patient's overall health status, and other considerations.
Latent tuberculosis infection occurs when TB bacteria are present in a person's body, but are not causing illness or symptoms. It is not contagious, and preventive treatment is crucial to avoid the progression...
Latent tuberculosis infection occurs when TB bacteria are present in a person's body, but are not causing illness or symptoms. It is not contagious, and preventive treatment is crucial to avoid the progression...