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Experimental cutaneous protothecosis in mice: epithelioid cell granuloma formation
Y Horiuchi1, N Tomizawa, I Higuchi
1Division of Dermatology, Kashima Rosai Hospital, Ibaraki, Japan.
The Journal of Dermatology
|February 1, 1991
Abstract:
Prototheca wickerhamii, isolated from skin biopsy specimens of a patient with cutaneous protothecosis, were cultured in Sabouraud's medium and inoculated in the skin of 8 ICR albino mice and 3 BALB/c mice. Only in 3 ICR albino mice and 3 BALB/c mice were organisms found in skin tissue, as confirmed by identification of organisms by staining with periodic acid-Schiff (PAS) stain and culture. Histologic findings from affected nodular skin lesions indicated epithelioid cell granuloma and histiocytic cell infiltrates in the dermis and subcutaneous tissue.