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Related Experiment Videos

Autophagy in MHC class II antigen processing.

Andrew B Strawbridge1, Janice S Blum

  • 1Department of Microbiology and Immunology, Center for Immunobiology, Indiana University School of Medicine, 635 Barnhill Drive, MS420, Indianapolis, IN 46202, USA.

Current Opinion in Immunology
|November 30, 2006
PubMed
Summary
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Adaptive immunity relies on CD4 T-cells recognizing MHC class II molecules presenting antigens. Autophagy pathways deliver endogenous antigens to MHC class II, ensuring immune recognition.

Area of Science:

  • Immunology
  • Cell Biology
  • Molecular Biology

Background:

  • Durable adaptive immunity requires CD4 T-cell recognition of peptides presented by MHC class II molecules.
  • Both exogenous and endogenous antigens are presented by MHC class II.
  • Endogenous antigens access MHC class II through various intracellular autophagic pathways.

Purpose of the Study:

  • To elucidate the mechanisms by which endogenous antigens access MHC class II molecules.
  • To understand the role of different autophagy pathways in antigen presentation.
  • To investigate the interplay between autophagy pathways in regulating antigen access.

Main Methods:

  • The study reviews known intracellular autophagic routes for antigen processing and presentation.
  • It discusses the roles of macroautophagy, microautophagy, and chaperone-mediated autophagy.

Related Experiment Videos

  • The concept of cross-talk between autophagy pathways is examined.

    • Main Results:

    • Macroautophagy delivers antigens into autophagosomes for processing and MHC class II presentation.
    • Cytoplasmic proteases process other endogenous antigens, which then enter the endosomal network via chaperone-mediated autophagy to intersect MHC class II.
    • Cross-talk between autophagy pathways, especially under stress, balances pathway efficiency.

    Conclusions:

    • Autophagy pathways provide diverse routes for endogenous antigens to reach MHC class II molecules.
    • Interplay between autophagy pathways ensures broad access of MHC class II to antigens from various intracellular compartments.
    • This intricate system is crucial for robust adaptive immune responses.