Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

What is immune privilege (not)?

Ian Galea1, Ingo Bechmann, V Hugh Perry

  • 1CNS Inflammation Group, School of Biological Sciences, University of Southampton, SO16 7PX, UK. I.Galea@soton.ac.uk

Trends in Immunology
|November 30, 2006
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Evaluating the effectiveness of simvastatin in slowing the progression of disability in secondary progressive multiple sclerosis: a synopsis of MS-STAT2, a multicentre, randomised controlled, double-blind, phase 3 clinical trial.

Health technology assessment (Winchester, England)·2026
Same author

Expression of GPR34 in microglia remains stable in human Alzheimer's disease.

Acta neuropathologica·2026
Same author

A deep-learning framework reveals whole-body perturbations at cell level.

Nature·2026
Same author

Erythrocyte Fragility in Progressive Multiple Sclerosis.

European journal of neurology·2026
Same author

Diet-Driven Microglial Activation: Region-Specific Neuroinflammation in the Mouse Brain.

Brain sciences·2026
Same author

Modulating food intake by nasal application of peptides targeting melanocortin 4 receptor and ghrelin receptor systems.

Brain communications·2026
Same journal

Mitochondrial Ca<sup>2+</sup> signaling: A metabolic rheostat defining tumor and immune cell fate.

Trends in immunology·2026
Same journal

Cross-priming underlies the efficacy of antibody-drug conjugates and immunotherapy combinations.

Trends in immunology·2026
Same journal

Gut microbiome metabolites meet immunometabolism in inflammatory bowel disease.

Trends in immunology·2026
Same journal

Metabolic regulatory nodes of the inflammasome and inflammatory cell death.

Trends in immunology·2026
Same journal

T cell control of the intestinal barrier and gut microbiota during ageing.

Trends in immunology·2026
Same journal

Context-dependent androgen control of T cell immunity.

Trends in immunology·2026
See all related articles

The central nervous system

Area of Science:

  • Neuroimmunology
  • Central Nervous System (CNS) Research

Background:

  • The concept of central nervous system (CNS) immune privilege is critical for limiting inflammation-induced damage in the brain.
  • This longstanding notion has accumulated misconceptions and lacks precise definition.

Purpose of the Study:

  • To redefine CNS immune privilege based on recent scientific data.
  • To clarify misconceptions surrounding CNS immune privilege.

Main Methods:

  • Review and synthesis of recent scientific literature on CNS immunity.
  • Analysis of factors influencing CNS immune privilege, including age and brain region.

Main Results:

  • CNS immune privilege is not absolute and varies significantly with age and brain region.

Related Experiment Videos

  • The blood-brain barrier is not the sole factor; specialized adaptive immunity and CNS-resident cells play key roles.
  • Cell-mediated antigen drainage from the CNS is limited, while soluble drainage is established.

    • Conclusions:

    • CNS immune privilege is actively maintained by the immunoregulatory properties of CNS-resident cells and their microenvironment.
    • A precise understanding of CNS immune privilege requires considering its dynamic nature and multifaceted mechanisms.