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Related Experiment Videos

Abnormal orbitofrontal development due to prematurity.

M Giménez1, C Junqué, P Vendrell

  • 1Department of Psychiatry and Clinical Psychobiology, Faculty of Medicine, University of Barcelona, Spain.

Neurology
|November 30, 2006
PubMed
Summary
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Very-preterm birth (VPTB) significantly impacts secondary sulcal development in adolescents, showing reduced depth. This brain maturation impairment from prematurity is not reversible in childhood.

Area of Science:

  • Neuroscience
  • Developmental Biology
  • Medical Imaging

Background:

  • Premature birth is a significant concern impacting neurodevelopment.
  • Sulcal formation, a key aspect of brain development (gyrification), begins in utero.
  • Understanding the long-term effects of prematurity on brain structure is crucial for potential interventions.

Purpose of the Study:

  • To investigate the effects of very-preterm birth (VPTB) on the development of specific sulci in the human brain.
  • To compare sulcal formation in adolescents with a history of VPTB to those born at term.

Main Methods:

  • Evaluation of primary olfactory and secondary orbital sulci depth and volume in 22 VPTB adolescents and matched controls.
  • Utilized Anatomist/BrainVISA 3.0.1 for sulci quantification.

Related Experiment Videos

  • Employed voxel-based morphometry (VBM) to assess gray and white matter volume in the orbitofrontal region.

    • Main Results:

    • Adolescents with VPTB exhibited significantly reduced depth in secondary orbital sulci compared to controls.
    • No significant difference was observed in the primary olfactory sulcus depth between groups.
    • VBM analysis revealed reduced gray matter volume in the orbital region of VPTB individuals.

    Conclusions:

    • Very-preterm birth adversely affects cerebral gyrification, specifically impacting secondary sulcal development.
    • This impairment in brain maturation due to prematurity appears to be irreversible during childhood.
    • Further research into the factors driving abnormal brain maturation in VPTB is needed to develop effective interventions.