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Elevated serum angiogenin levels in ALS.

S Cronin1, M J Greenway, S Ennis

  • 1Department of Physiology, Royal College of Surgeons in Ireland, Ireland. scronin@rcsi.ie

Neurology
|November 30, 2006
PubMed
Summary
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Serum angiogenin levels are modestly elevated in patients with Amyotrophic Lateral Sclerosis (ALS). This finding suggests angiogenin may serve as a potential biomarker for ALS diagnosis and progression.

Area of Science:

  • Neuroscience
  • Biochemistry
  • Genetics

Background:

  • Hypoxia-responsive genes, including vascular endothelial growth factor (VEGF) and angiogenin (ANG), are implicated in Amyotrophic Lateral Sclerosis (ALS) pathogenesis.
  • Mutations in ANG, a hypoxia-responsive gene, are linked to human ALS.
  • Angiogenin's role in regulating VEGF expression in endothelium is established, but its serum levels in ALS patients remain unassessed.

Purpose of the Study:

  • To investigate serum angiogenin and VEGF levels in patients diagnosed with Amyotrophic Lateral Sclerosis (ALS).
  • To determine if serum angiogenin can serve as a potential biomarker for ALS.

Main Methods:

  • Quantified serum angiogenin and VEGF levels in 79 ALS patients and 72 healthy controls using a quantitative sandwich enzyme-linked immunoassay.

Related Experiment Videos

  • Assessed levels at diagnosis and tracked changes at 12 months.

    • Main Results:

    • Patients with ALS showed significantly higher serum angiogenin levels compared to controls (p = 0.006).
    • No significant difference in serum VEGF levels was observed between ALS patients and controls (p = 0.55).
    • Elevated angiogenin levels were more pronounced in spinal-onset ALS compared to bulbar-onset ALS.

    Conclusions:

    • A modest elevation in serum angiogenin is observed in ALS patients at diagnosis.
    • Serum angiogenin warrants further investigation as a potential biomarker for ALS diagnosis and disease progression prediction.