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Updated: Jul 18, 2026
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Noninvasive Sampling of Mucosal Lining Fluid for the Quantification of In Vivo Upper Airway Immune-mediator Levels
Published on: August 7, 2017
Microarray-based identification of novel biomarkers in asthma.
Kenji Izuhara1, Hirohisa Saito
1Division of Medical Biochemistry, Department of Biomolecular Sciences, Center for Comprehensive Community Medicine, Saga Medical School, Japan.
Summary
Microarray technology helps identify novel biomarkers for bronchial asthma, a complex lung inflammation disorder. These biomarkers aid in diagnosis, treatment strategies, and understanding disease mechanisms.
Area of Science:
- Immunology
- Genomics
- Respiratory Medicine
Background:
- Bronchial asthma is a complex lung disorder influenced by genetic and environmental factors.
- It involves Th2-type inflammation triggered by allergen inhalation.
- The intricate pathogenesis of asthma remains incompletely understood.
Purpose of the Study:
- To review microarray-based functional genomics studies on bronchial asthma.
- To focus on the identification of novel biomarkers for asthma.
- To enhance understanding of asthma pathogenesis and therapeutic targets.
Main Methods:
- Utilizing microarray technology for functional genomics analysis.
- Analyzing whole gene expression profiling in asthma research.
- Reviewing published studies employing microarrays for asthma.
Main Results:
- Microarray analyses have revealed novel insights into asthma pathogenesis.
- Several potential biomarkers for asthma diagnosis have been identified.
- New therapeutic targets and mechanisms underlying asthma are emerging.
Conclusions:
- Microarray technology is a powerful tool for asthma research.
- Identified biomarkers can improve asthma diagnosis and treatment.
- Continued functional genomics studies are crucial for clarifying asthma pathogenesis.
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