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Related Concept Videos

Parkinson's Disease: Overview01:15

Parkinson's Disease: Overview

Neurodegenerative disorders are progressive diseases that cause irreversible damage and loss to neurons in specific brain areas. Examples of these disorders include Parkinson's disease, Alzheimer's disease, Multiple Sclerosis (MS), and Amyotrophic Lateral Sclerosis (ALS). These disorders share characteristics such as proteinopathies, selective neuronal vulnerability, and a complex interplay between genetic and environmental factors. The primary therapeutic goal for these conditions is to...
Parkinson Disease l: Introduction01:24

Parkinson Disease l: Introduction

Parkinson’s disease is a chronic, progressive neurodegenerative disorder that primarily affects movement. It is characterized by motor symptoms such as resting tremors, muscle rigidity, bradykinesia (slowness of movement), and postural instability. Patients may notice hand tremors at rest, stiffness during movement, or a shuffling gait. In addition to motor features, non-motor symptoms include sleep disturbances, mood and behavioral changes, constipation, and cognitive impairment, all of which...
Parkinson's Disease: Treatment01:24

Parkinson's Disease: Treatment

Neurodegenerative disorders, such as Parkinson's Disease (PD), involve the gradual and irreversible destruction of neurons in particular brain areas. These disorders exhibit standard features like proteinopathies, selective vulnerability of some neurons, and an interaction of intrinsic properties, genetics, and environmental influences in neural injury.
Parkinson's Disease is primarily a result of the loss of dopaminergic neurons in the substantia nigra pars compacta. The cornerstone of its...
Parkinson Disease ll: Pathophysiology01:24

Parkinson Disease ll: Pathophysiology

Parkinson disease (PD) is a progressive neurodegenerative disorder primarily affecting movement, with additional non-motor features. Its pathophysiology involves complex interactions among genetic susceptibility, environmental exposures, and cellular dysfunction, including dopaminergic neuron loss, protein aggregation, and mitochondrial impairment.Selective NeurodegenerationA key feature is the degeneration of dopaminergic neurons in the substantia nigra pars compacta, leading to reduced...
Neural Regulation01:37

Neural Regulation

Digestion begins with a cephalic phase that prepares the digestive system to receive food. When our brain processes visual or olfactory information about food, it triggers impulses in the cranial nerves innervating the salivary glands and stomach to prepare for food.
Brainstem01:19

Brainstem

The brainstem, located inferior to the brain and superior to the spinal cord, serves as a bridge between the cerebrum and the spinal cord. It plays a vital role in relaying information and controlling critical life functions. It comprises three primary regions: the midbrain, pons, and medulla oblongata.
The Midbrain
The midbrain is located beneath the diencephalon and connects the cerebrum with the lower parts of the brain. The cerebral peduncles are prominent midbrain structures that house the...

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[Functional Movement Disorders That Do Not Improve after Explaining the Diagnosis: Do Not Treat the Disease, Treat the Patient].

Brain and nerve = Shinkei kenkyu no shinpo·2022
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Postural Abnormality in Parkinson's Disease: A Large Comparative Study With General Population.

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GCH1 mutations in dopa-responsive dystonia and Parkinson's disease.

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Related Experiment Video

Updated: Jul 18, 2026

Characterizing the Relationship Between Eye Movement Parameters and Cognitive Functions in Non-demented Parkinson's Disease Patients with Eye Tracking
07:26

Characterizing the Relationship Between Eye Movement Parameters and Cognitive Functions in Non-demented Parkinson's Disease Patients with Eye Tracking

Published on: September 26, 2019

Dropped head in Parkinson's disease.

Ken-ichi Fujimoto1

  • 1Department of Neurology, Jichi Medical University, 3311-1 Yakushiji, Shimotsuke-city, Tochigi, 329-0498, Japan. kenchan@jichi.ac.jp

Journal of Neurology
|November 30, 2006
PubMed
Summary

Dropped head, characterized by forward trunk bending, is common in Parkinson's disease (PD). Its cause may be neck muscle dystonia or weakness, with inconsistent treatment responses.

Area of Science:

  • Neurology
  • Movement Disorders

Background:

  • The term "dropped head" describes forward bending of the trunk and head, first noted in Gerlier disease and subsequently in various neuromuscular conditions.
  • While considered rare in Parkinson's disease (PD), this study suggests dropped head is relatively common in PD patients.
  • Disproportionate antecollis, a form of dropped head, occurs in about half of multiple system atrophy (MSA) cases and is considered dystonic.

Observation:

  • Dropped head is frequently observed in Parkinson's disease, contrary to its rarity in literature.
  • The condition progresses subacutely over several days.
  • Mechanisms include flexor neck muscle dystonia or extensor muscle weakness.

Findings:

  • The response to anti-Parkinsonian medications is inconsistent; levodopa may help some, while dopamine agonists can worsen symptoms.

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Induction and Assessment of Levodopa-induced Dyskinesias in a Rat Model of Parkinson's Disease
05:51

Induction and Assessment of Levodopa-induced Dyskinesias in a Rat Model of Parkinson's Disease

Published on: October 14, 2021

Related Experiment Videos

Last Updated: Jul 18, 2026

Characterizing the Relationship Between Eye Movement Parameters and Cognitive Functions in Non-demented Parkinson's Disease Patients with Eye Tracking
07:26

Characterizing the Relationship Between Eye Movement Parameters and Cognitive Functions in Non-demented Parkinson's Disease Patients with Eye Tracking

Published on: September 26, 2019

Induction and Assessment of Levodopa-induced Dyskinesias in a Rat Model of Parkinson's Disease
05:51

Induction and Assessment of Levodopa-induced Dyskinesias in a Rat Model of Parkinson's Disease

Published on: October 14, 2021

  • Muscle afferent block with lidocaine and ethanol shows effectiveness.
  • Botulinum toxin injections and stereotactic neurosurgery have limited or controversial effects.
  • Implications:

    • Early diagnosis and prompt intervention are crucial to prevent irreversible muscle damage from chronic extensor muscle overstretch.
    • Understanding the specific mechanisms in PD can guide targeted therapeutic strategies.
    • Further research is needed to clarify the inconsistent treatment responses and optimize management for dropped head in PD.