[Determination of haloperidol in fingernail/toenails by LC-ESI-Ms]

The report presents the possibility of using fingernails/ toenails to determine haloperidol levels. The described determinations were performed using the method of liquid chromatography coupled with electrospray-ionization mass spectrophotometry (LC-ESI-MS). In the course of the investigation, the authors developed a method for isolating haloperidol from nails and its identification. Determinations were performed in fingernail/toenail samples originating from individuals who had been administered haloperidol at least 6 months prior to sample collection. The materials demonstrated the presence of haloperidol in the following amount: fingernails - 67.3 +/- 6.49 pg/mg, toenails- 98.9 +/- 9.14 pg/mg.