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04:33
Methods for Detecting Cough and Airway Inflammation in Mice
Published on: August 2, 2024
Cough and asthma
Wissam Abouzgheib1, Melvin R Pratter, Thaddeus Bartter
1Division of Pulmonary and Critical Care Medicine, Cooper University Hospital, Camden, New Jersey, USA.
Current Opinion in Pulmonary Medicine
|November 30, 2006
Summary
Asthma is a common cause of chronic cough. Recent studies suggest cough-variant asthma is a spectrum of asthma, differing in inflammatory response and bronchoconstriction compared to classic asthma.
Area of Science:
- Pulmonology
- Allergy and Immunology
- Respiratory Medicine
Background:
- Asthma is a significant diagnosis in studies evaluating chronic cough.
- Differentiating cough-variant asthma from classic asthma remains an area of active research.
Purpose of the Study:
- To review and contextualize recent research on the relationship between cough and asthma.
- To explore the evolving understanding of cough-variant asthma.
Main Methods:
- Review of recent prospective studies on cough and asthma.
- Analysis of research differentiating cough-variant asthma from classic asthma based on bronchoconstrictor response, airway resistance, and biochemical markers.
Main Results:
- Asthma is frequently diagnosed in cough studies, though incidence varies by cough type (sub-acute vs. chronic).
- Studies indicate cough-variant asthma may have a blunted bronchoconstrictor response and altered airway resistance compared to classic asthma.
- Biochemical differences, such as vascular endothelial growth factor levels, may distinguish cough-variant from classic asthma.
Conclusions:
- Emerging data positions cough-variant asthma as part of a continuum of asthma symptom expression.
- The inflammatory response in cough-variant asthma may differ from that in classic asthma.
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