Development of methods for skin barrier peeling tests

Area of Science:

• Biomaterials Science
• Adhesion Science
• Medical Device Testing

Background:

• Evaluating the adhesive properties of skin barriers is crucial for medical applications.
• Traditional testing methods using stainless steel plates can lead to inaccurate measurements due to skin barrier stretching and breakage.

Purpose of the Study:

• To develop a more effective and reliable method for assessing the adhesive properties of skin barriers.
• To establish a testing protocol that overcomes the limitations of existing methods.

Main Methods:

• A novel approach involved applying a fluorocarbon polymer film to the adhesive surface of skin barriers.
• 180-degree peeling tests were conducted using a Tensilon Automatic Elongation Tester in controlled environmental chambers.
• The experimental design incorporated partial control, randomization, and repetition, adhering to standardized methodology (JIS Z0297) where applicable.

Main Results:

• Fluorocarbon polymer films demonstrated ease of removal, flexibility, and elongation tolerance, ideal for adhesive testing.
• The new method yielded reproducible measurements of skin barrier adhesion by peeling the polymer films.
• Results from the new method were compared against a control group using the conventional stainless steel plate method.

Conclusions:

• The developed testing method allows for chronological measurement of skin barrier adhesion over extended periods (24, 48 hours, and longer).
• This technique offers a more accurate and reliable evaluation of skin barrier adhesive properties compared to conventional methods.