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Lobar pneumonia caused by nontyphoidal Salmonella in a Malawian child

Limangeni A Mankhambo1, Kwame W Chiwaya, Agib Phiri

  • 1Malawi-Liverpool-Wellcome Trust Programme of Clinical Tropical Research and Department of Paediatrics, College of Medicine, Blantyre, Malawi.

The Pediatric Infectious Disease Journal
|November 30, 2006
PubMed

Insights

Nontyphoidal Salmonella (NTS) can cause severe pneumonia in children, even without HIV. Early diagnosis and appropriate antibiotics like ceftriaxone are crucial for treatment.

Area of Science:

  • Infectious Diseases
  • Pediatrics
  • Microbiology

Background:

  • Nontyphoidal Salmonella (NTS) is a known cause of bacteremia in malaria-endemic regions.
  • The role of NTS in causing pneumonia, particularly in children, remains less understood.

Observation:

  • A 16-month-old girl, previously treated for severe malaria, developed pneumonia.
  • Lung aspirate culture confirmed Nontyphoidal Salmonella as the causative agent.
  • The patient was initially unresponsive to benzylpenicillin and gentamicin therapy.

Findings:

  • Nontyphoidal Salmonella was identified as the cause of pneumonia via lung aspirate culture.
  • Treatment with ceftriaxone led to clinical improvement, suggesting its efficacy.

Implications:

  • This case highlights Nontyphoidal Salmonella as a potential cause of severe pneumonia in pediatric populations in malaria-endemic areas.
  • It underscores the importance of considering NTS in the differential diagnosis of pneumonia, especially in children with a recent history of malaria.
  • The case also suggests ceftriaxone as an effective therapeutic option for NTS pneumonia.

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