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[Multiple mononeuropathy associated to treatment with pravastatin]
I Abellán-Miralles1, R M Sánchez-Pérez, N Pérez-Carmona
1Unidad de Neurología, Hospital de la Marina Baixa, Partina Galandú s/n, E-03570 Villajoyosa, Alicante, Spain. iabellanm@jmalladaf.jazztel.es
Revista De Neurologia
|November 30, 2006
Summary
Statins can cause neuropathy, a rare complication. This case highlights multiple mononeuropathy, an atypical presentation of statin-induced neuropathy that is potentially reversible.
Area of Science:
- Neurology
- Pharmacology
Background:
- Statins are widely prescribed cholesterol-lowering drugs.
- Neuropathy is a rare but reported adverse effect of statin therapy.
- The typical presentation is a symmetrical, distal axonal polyneuropathy.
Observation:
- A 51-year-old female developed distal paresthesias and gait instability after starting pravastatin.
- Electromyography confirmed multiple mononeuritis, an atypical form of neuropathy.
- Symptoms improved upon drug withdrawal and recurred upon re-challenge.
Findings:
- This is the second reported case of multiple mononeuropathy associated with statin use.
- The study confirms that statin-induced neuropathy can manifest in atypical forms beyond symmetrical polyneuropathy.
- Cessation of pravastatin led to significant symptom improvement, suggesting a causal link.
Implications:
- Clinicians should consider statin-induced neuropathy, including atypical forms like multiple mononeuropathy, in patients presenting with relevant symptoms.
- Early recognition and drug withdrawal can lead to potentially reversible neuropathy.
- Despite the low risk, increased statin use may lead to more reported cases in the future.
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