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Updated: Jul 18, 2026

Association Between Sleep Quality and Cognitive Symptoms in Patients with Major Depressive Disorder
Published on: April 26, 2024
Sleep and depression
1Department of Neuropsychiatry, University of Missouri-Columbia School of Medicine, USA.
Abstract:
Depression results in severe sleep disturbance. The "depressed brain" takes longer to initiate sleep, shortens the period to dreaming sleep, spends little or no time in "deep sleep" and is subject to hyperactive brain regions during sleep. Antidepressants rectify the sleep disturbance and restore normal sleep architecture and presumably normal brain metabolism during sleep. Early intervention may lead to a decrease in neuronal cell loss due to depression, and better long-term outcomes for mood disorders.
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