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Updated: Jul 18, 2026
10:33
Isolation and Characterization Of Chimeric Human Fc-expressing Proteins Using Protein A Membrane Adsorbers And A Streamlined Workflow
Published on: January 8, 2014
Future of antibody purification
Duncan Low1, Rhona O'Leary, Narahari S Pujar
1Amgen, Thousand Oaks, CA, USA.
Summary
Antibody purification platforms are evolving due to increased antibody therapies and upstream gains. This review surveys promising new downstream technologies for future antibody manufacturing processes.
Area of Science:
- Biotechnology
- Process Engineering
- Pharmaceutical Sciences
Background:
- Established antibody purification platforms are widely used in commercialized antibody manufacturing.
- Increasing demand for antibody therapies and enhanced upstream productivity necessitate downstream process evolution.
- Current downstream processes face challenges in keeping pace with upstream advancements.
Purpose of the Study:
- To survey emerging technologies for antibody purification.
- To assess the promise of these technologies for future antibody manufacturing platforms.
- To identify key innovations driving downstream process evolution.
Main Methods:
- Comprehensive review of current and emerging antibody purification technologies.
- Analysis of technological advancements in late-stage antibody development processes.
- Comparative assessment of the potential impact of various downstream technologies.
Main Results:
- Evolution of antibody purification platforms is evident in late-stage development.
- Several disruptive technologies show significant promise for integration into future platforms.
- Upstream productivity improvements are a key driver for downstream innovation.
Conclusions:
- The antibody purification landscape is dynamic, with ongoing technological evolution.
- New technologies are crucial for meeting the future demands of antibody therapy production.
- Strategic integration of promising downstream technologies will enhance manufacturing efficiency and economics.
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