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The mouse genome database (MGD): new features facilitating a model system.

Janan T Eppig1, Judith A Blake, Carol J Bult

  • 1The Jackson Laboratory 600 Main Street, Bar Harbor, ME 04609, USA.

Nucleic Acids Research
|December 1, 2006
PubMed
Summary
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The Mouse Genome Database (MGD) offers integrated data on mouse genetics and biology, aiding human disease research. It provides comprehensive tools for comparative analysis and hypothesis generation in translational science.

Area of Science:

  • Genomics
  • Bioinformatics
  • Comparative Biology

Background:

  • The laboratory mouse is a key model organism for understanding human development and disease.
  • The Mouse Genome Database (MGD) serves as a central resource for mouse genetics, genomics, and biology data.

Purpose of the Study:

  • To facilitate the use of mouse models for studying human diseases.
  • To enable the development of translational research hypotheses through comparative analyses.
  • To provide integrated access to comprehensive mouse data.

Main Methods:

  • Data integration from diverse sources including research centers, labs, and literature.
  • Expert human curation and automated processes for data management.
  • Incorporation of key ontologies like Gene Ontology (GO) and Mammalian Phenotype Ontology.

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Main Results:

  • MGD provides access to gene functions, phenotypes, disease models, sequence data, polymorphisms, and mapping data.
  • The database supports complex queries integrating phenotypic, functional, and genetic information.
  • Recent updates include SNP data, knockout mouse phenotypes, and enhanced visualization tools.

Conclusions:

  • MGD is an authoritative resource for mouse nomenclature and GO annotations.
  • It empowers data mining and hypothesis generation for translational research.
  • The database continuously improves to support the scientific community.