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Related Experiment Videos

New antihistamines: a critical view.

Inês Cristina Camelo-Nunes1

  • 1Departamento de Pediatria, Universidade Federal de São Paulo - Escola Paulista de Medicina (UNIFESP-EPM), São Paulo, SP, Brazil. iccamelo@uol.com.br

Jornal De Pediatria
|December 1, 2006
PubMed
Summary
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The term "third-generation antihistamines" is misleading, as current compounds lack clear definitions and clinical advantages. New antihistamines require demonstrated safety and efficacy to earn this classification.

Area of Science:

  • Pharmacology
  • Allergy and Immunology

Background:

  • H1 antihistamines are crucial for treating allergic disorders.
  • Second-generation antihistamines offer improved specificity and reduced sedation compared to first-generation agents.
  • Concerns exist regarding cardiotoxicity and drug interactions with some newer antihistamines.

Purpose of the Study:

  • To critically evaluate recent H1 antihistamines and the terminology used to describe them.
  • To review evidence on the role of antihistamines in allergic disorder treatment.
  • To clarify the definition and clinical implications of

Main Methods:

  • Systematic review of original articles, reviews, and consensus documents.
  • Literature search conducted on MEDLINE and PubMed databases from 1998 to 2006.

Related Experiment Videos

  • Keyword used for search: "antihistamines".

    • Main Results:

    • Second-generation antihistamines exhibit greater H1 receptor specificity and lower central nervous system penetration, leading to fewer sedative effects.
    • While generally better tolerated, some second-generation antihistamines have shown adverse effects, notably cardiotoxicity.
    • Newer compounds, including active metabolites termed "third-generation antihistamines," possess independent anti-inflammatory properties, but their classification lacks clear definition and clinical consensus.

    Conclusions:

    • Current H1 antihistamines do not meet the criteria for