Recent progress in the use of ionic polymers as pseudostationary phases for EKC

Area of Science:

• Analytical Chemistry
• Separation Science
• Polymer Chemistry

Background:

• Polymeric pseudostationary phases (PSPs) have emerged as versatile materials in electrokinetic chromatography (EKC).
• Since 2004, significant advancements have been made in the development and application of PSPs for EKC.
• These materials offer tunable properties for enhanced separation capabilities.

Purpose of the Study:

• To provide a comprehensive review of polymeric pseudostationary phases (PSPs) for electrokinetic chromatography (EKC).
• To summarize the characterization and application of both achiral and chiral polymeric PSPs.
• To highlight the integration of polymeric PSPs in EKC coupled with mass spectrometry.

Main Methods:

• Literature review of research published since 2004 on polymeric PSPs in EKC.
• Analysis of characterization techniques for polymeric PSPs.
• Examination of separation mechanisms for achiral and chiral analytes using polymeric PSPs.
• Review of studies combining EKC with mass spectrometry using polymeric PSPs.

Main Results:

• A wide array of achiral and chiral polymers have been successfully employed as PSPs in EKC.
• Polymeric PSPs demonstrate effective performance in separating various classes of compounds, including enantiomers.
• The coupling of EKC with mass spectrometry using polymeric PSPs enables sensitive and selective detection.

Conclusions:

• Polymeric PSPs have significantly advanced the field of EKC, offering improved separation efficiency and versatility.
• The ongoing development of novel polymeric materials continues to expand the applicability of EKC.
• The combination of EKC with mass spectrometry, facilitated by polymeric PSPs, represents a powerful analytical tool.