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Updated: Jul 18, 2026

Preparation and Testing of Impedance-based Fluidic Biochips with RTgill-W1 Cells for Rapid Evaluation of Drinking Water Samples for Toxicity
Published on: March 7, 2016
Methods validation for the determination of trihalomethanes in drinking water
Monica Culea1, Onuc Cozar, Dumitru Ristoiu
1Babes Bolyai University of Cluj-Napoca, M. Kogalniceanu str. 1., 400084 Cluj-Napoca, Romania. mculea@phys.ubbcluj.ro
Abstract:
Trihalomethanes (THMs), chlorinated by-products in drinking water, have been determined by comparing some analytical methods, based on the following techniques: liquid-liquid extraction-gas chromatography-mass spectrometry (LLE-GC-MS), headspace-gas chromatography-mass spectrometry (headspace-GC-MS) and purge and trap-gas chromatography-mass spectrometry (PT-GC-MS). The mass spectrometer was operated in the SIM mode. The quantitative methods were validated and compared to the ability to identify and to measure reliably the yields of the toxic compounds. Good validation parameters were obtained for each method.
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Data Validation
Key parameters for method validation include:
Testing Water Quality