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Updated: Jul 18, 2026

Nucleoside Triphosphates - From Synthesis to Biochemical Characterization
Published on: April 3, 2014
Biosynthetic study of FR-900848: origin of the aminodeoxynucleoside part
Hiroaki Watanabe1, Tetsuo Tokiwano, Hideaki Oikawa
1Division of Chemistry, Graduate School of Science, Hokkaido University, Sapporo 060-0810, Japan. hoik@sci.hokudai.ac.jp
Abstract:
Biosynthetic studies of the antifungal agent, FR-900848, were undertaken by feeding experiments with D-[U-13C,]glucose, L-[4-13C]aspartate, [5,5-2H,]dihydrouridine and [5,5-2H2]dihydrouracil. The 5"-amino-5"-deoxy-5',6'-dihydrouridine moiety was derived from ribose and aspartate. Based on the feeding experiments, a detailed biosynthetic pathway producing the aminodeoxydihydrouridine moiety of FR-900848 was proposed.
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