Related Experiment Video
Updated: Jul 18, 2026

Pooled CRISPR-Based Genetic Screens in Mammalian Cells
Published on: September 4, 2019
The trade-off between population and individual benefit of screening
1Institut für Epidemiologie und Sozialmedizin, Universität Münster. hense@uni-muenster.de
Abstract:
In cancer screening there is a delicate balance between the benefit for the population and the individual benefit. In different European mammography and other screening programmes major differences were observed regarding detection rates and false positive rates. With massive screening programmes starting in Germany, careful evaluation of their performance and achievement is mandatory, including a determination of the false negative rates. This requires the determination of interval cancer rates on the basis of complete population-based cancer registries.
Related Concept Videos
Genetic Screens
Forward genetic screens
Forward or “classical” genetic screens involve creating random mutations in an organism’s DNA using radiation, mutagens, or insertion of additional bases, which result in visible changes...
Testing a Claim about Population Proportion
There are two methods of testing a claim about a population proportion: (1) Using the sample proportion from the data where a binomial distribution is approximated to the normal distribution and (2) Using the binomial probabilities calculated from the data.
The first method uses normal distribution as an approximation to the binomial distribution. The requirements are as follows: sample size is large...
Preventive Healthcare Services
Types of Biopharmaceutical Studies: Controlled and Non-Controlled Approaches
Non-controlled studies, commonly employed for initial exploration, lack a control group, rendering them susceptible to biases and external influences. In contrast, controlled...
Analysis of Population Pharmacokinetic Data
Receiver Operating Characteristic Plot
