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Updated: Jul 18, 2026
12:35
In vivo Liver Endocytosis Followed by Purification of Liver Cells by Liver Perfusion
Published on: November 10, 2011
Hepatocytes detoxify Atuna racemosa extract.
1Complementary and Integrative Medicine Program, Mayo Clinic College of Medicine, Rochester, MN 55905, USA. buenz@biosciential.com
Experimental Biology and Medicine (Maywood, N.J.)
|December 2, 2006
Summary
Atuna racemosa extract shows low potential for liver toxicity in cell models. Further in vivo studies are recommended to confirm the safety of this traditional medicine plant.
Area of Science:
- Pharmacology
- Toxicology
- Hepatology
Background:
- Traditional medicine plants can possess hepatotoxic properties.
- Atuna racemosa is used in traditional medicine with limited toxicity data.
- Assessing potential liver toxicity is crucial for A. racemosa.
Purpose of the Study:
- To evaluate the potential hepatotoxicity of Atuna racemosa extract.
- To investigate the interaction of A. racemosa extract with liver cells.
Main Methods:
- Utilized Jurkat T cells and HepG2 hepatocytes as in vitro models.
- Conducted a conditioned media experiment to assess extract effects.
Main Results:
- The Atuna racemosa extract demonstrated low hepatotoxicity in the tested cell lines.
- Conditioned media experiments suggest the liver may detoxify A. racemosa extract.
Conclusions:
- In vitro results indicate a low risk of hepatotoxicity from Atuna racemosa extract.
- Further in vivo toxicology investigations are warranted based on these findings.
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