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Revenge of the NRD: preferential degradation of nonfunctional eukaryotic rRNA
1Howard Hughes Medical Institute, Department of Molecular and Cellular Biology, University of Arizona, Tucson, Arizona 85721, USA.
Developmental Cell
|December 5, 2006
Abstract:
Eukaryotic cells have several quality control systems that monitor the proper processing of RNAs during RNA biogenesis or the function of cytoplasmic mRNAs. A recent study in Molecular Cell by LaRiviere et al. (2006) shows that after production, mature rRNA is also subject to quality control and nonfunctional ribosomes are targeted for destruction by a novel ribosome surveillance mechanism.
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