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Published on: March 15, 2016

Serum VEGF--as a prognostic factor of atherosclerosis

Kuriko Kimura1, Teruto Hashiguchi, Takahisa Deguchi

  • 1Department of Neurology and Geriatrics, Graduate School of Medical and Dental Sciences, Kagoshima University, Japan.

Atherosclerosis
|December 5, 2006
PubMed

Insights

Serum vascular endothelial growth factor (VEGF) levels may indicate atherosclerosis risk, particularly in men. Higher VEGF concentrations correlated with factors like platelet count and body fat, suggesting a link to disease progression.

Area of Science:

  • Cardiovascular Biology
  • Biochemistry
  • Medical Diagnostics

Background:

  • Vascular Endothelial Growth Factor (VEGF) plays a role in atherosclerosis pathogenesis.
  • Serum VEGF concentration is being investigated as a potential biomarker for atherosclerosis.

Purpose of the Study:

  • To evaluate the utility of serum VEGF concentration as an index for atherosclerosis.
  • To analyze the relationship between serum VEGF levels and various physiological parameters in adults.

Main Methods:

  • Serum VEGF concentrations were analyzed in 443 adult participants during medical checkups.
  • Correlations were examined between serum VEGF levels and factors including platelet count, body fat percentage, leukocyte count, and HDL-cholesterol.
  • Multiple regression analysis was performed to identify key predictors of serum VEGF concentration in men.

Main Results:

  • Mean serum VEGF was significantly higher in men (229 pg/ml) than women (182 pg/ml).
  • Platelet count showed a positive correlation with serum VEGF in both genders.
  • In men, serum VEGF correlated with platelet count, body fat percentage, leukocyte count, and HDL-cholesterol (negatively).
  • Male smokers exhibited higher serum VEGF levels compared to non-smokers.

Conclusions:

  • Serum VEGF concentration may be closely linked to atherosclerosis acceleration, especially in men.
  • Factors such as platelet count, body fat, leukocyte count, and HDL-cholesterol influence serum VEGF levels in men.
  • Smoking status significantly impacts VEGF levels and related biomarkers in men.

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