Related Experiment Video
Updated: Jul 18, 2026
07:51
The Application of 1% Methylene Blue Dye As a Single Technique in Breast Cancer Sentinel Node Biopsy
Published on: June 1, 2019
[Feasibility and technical problems of sentinel node analysis in melanoma]
A Mebazaa1, D Kerob, M-E Toubert
1Service de dermatologie-II, hôpital Saint-Louis, 1, avenue Claude-Vellefaux, 75475 Paris cedex 10, France.
Annales De Chirurgie Plastique Et Esthetique
|December 5, 2006
Summary
Sentinel lymph node (SLN) biopsy is feasible for melanoma staging, with a 16% micrometastasis detection rate. Positive SLN biopsy indicates a higher relapse risk, highlighting its prognostic value.
Area of Science:
- Oncology
- Surgical Pathology
- Medical Imaging
Context:
- Sentinel lymph node (SLN) biopsy has transformed solid tumor treatment, especially for melanoma.
- Accurate staging is crucial for melanoma prognosis and treatment planning.
Purpose:
- To assess the feasibility and prognostic value of SLN biopsy in melanoma patients.
- To evaluate the detection rate of micrometastases using SLN biopsy.
Summary:
- Lymphoscintigraphy identified SLNs in 97% of patients, with successful biopsy in 94%.
- Micrometastases were detected in 16% of SLNs, with a higher relapse rate in positive SLN cases (43%) compared to negative SLN cases (9.5%).
- Technical challenges in SLN identification and dissection were encountered in 9 cases.
Impact:
- Confirms the feasibility of SLN mapping and histological analysis in a clinical setting.
- Demonstrates the prognostic significance of SLN status in melanoma.
- Highlights the need for further studies on the advantages of SLN dissection over regional lymph node dissection for micrometastases.
