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Related Experiment Videos

A driving force for change: interstitial flow as a morphoregulator.

Joseph M Rutkowski1, Melody A Swartz

  • 1Institute of Bioengineering, Ecole Polytechnique Fédérale de Lausanne (EPFL), 1015 Lausanne, Switzerland.

Trends in Cell Biology
|December 5, 2006
PubMed
Summary

Interstitial flows, driven by tissue stresses, are crucial for nutrient transport and tissue maintenance. These fluid dynamics significantly impact cell biology, influencing development, disease, and immune responses.

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Area of Science:

  • Biomedical Engineering
  • Cell Biology
  • Physiology

Background:

  • Dynamic stresses in living tissues generate interstitial flows through the extracellular matrix.
  • Interstitial flows play vital roles in tissue maintenance and pathobiology, previously underestimated.
  • These flows are essential for nutrient transport within tissues.

Purpose of the Study:

  • To present evidence on the diverse effects of interstitial flow on cell biology.
  • To explore the roles of interstitial flow in various physiological and pathological processes.
  • To discuss the mechanisms by which interstitial flow influences tissue regulation.

Main Methods:

  • Review and synthesis of existing evidence on interstitial flow.
  • Analysis of studies investigating cellular responses to fluid flow.

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  • Examination of proposed mechanisms of morphoregulation induced by interstitial flow.

    • Main Results:

    • Interstitial flow impacts embryonic development, tissue morphogenesis, and remodeling.
    • It plays a role in inflammation, lymphedema, tumor biology, and immune cell trafficking.
    • Mechanisms include direct shear stress, matrix-cell transduction, and autologous gradient formation.

    Conclusions:

    • Interstitial flow is a significant factor in cell biology with broad implications.
    • Understanding these flows is critical for addressing various diseases and developmental processes.
    • Further research into the mechanisms of interstitial flow is warranted.