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Probing Cellular Activity Via Charge-Sensitive Quantum Nanoprobes.

Uri Zvi1, Shivam Mundhra2, David Ovetsky1

  • 1Pritzker School of Molecular Engineering, University of Chicago, Chicago, USA.

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|February 5, 2026
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Summary
This summary is machine-generated.

We developed a new quantum sensing method using nitrogen-vacancy (NV) centers to detect cellular activity. This technique reliably indicates inflammation by measuring charge shifts, offering a novel tool for biological research.

Keywords:
band bendingcharge transferdiamond nanocrystalselectric‐field sensingnitrogen‐vacancy centersquantum biosensingzero‐field splitting

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Area of Science:

  • Quantum sensing
  • Biophysics
  • Nanotechnology

Background:

  • Nitrogen-vacancy (NV) quantum sensors offer high sensitivity for single-cell analysis.
  • Mapping quantum measurements to cellular states remains a significant challenge.

Purpose of the Study:

  • Introduce a novel quantum sensing modality for detecting cellular activity changes.
  • Establish a foundation for probing complex cellular processes using physical measurements.

Main Methods:

  • Detecting environment-induced charge depletion in individual particles via transverse dipole term.
  • Measuring shifts in zero-field splitting (ZFS) as an indicator of cellular response.
  • Utilizing surface modification of diamond nanoprobes to suppress environmental shifts.

Main Results:

  • Charge-induced ZFS shifts reliably indicate lipopolysaccharide (LPS)-mediated inflammatory response in macrophages.
  • Surface modification differentiates electrostatic shifts from temperature variations and reduces toxicity.
  • Demonstrated a new sensing modality for complex cellular processes.

Conclusions:

  • The novel quantum sensing modality provides a reliable indicator of cellular inflammatory response.
  • Surface modification enhances sensor specificity and biocompatibility.
  • Findings advance NV spectroscopy in biological settings and single-cell analysis.