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Deep brain stimulation in neurologic disorders.

Casey Halpern1, Howard Hurtig, Jurg Jaggi

  • 1Department of Neurology, Penn Neurological Institute at Pennsylvania Hospital, Hospital of the University of Pennsylvania, Philadelphia, PA 19107, USA.

Parkinsonism & Related Disorders
|December 5, 2006
PubMed
Summary
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Deep brain stimulation (DBS) offers significant relief for Parkinson's disease (PD) and essential tremor (ET) patients. This surgical therapy enhances quality of life and reduces medication needs, with generally transient side effects.

Area of Science:

  • Neurosurgery
  • Neurology
  • Medical Devices

Background:

  • Deep brain stimulation (DBS) is a recognized surgical intervention for specific neurological movement disorders.
  • Medically intractable Parkinson's disease (PD) and essential tremor (ET) are primary indications for DBS.
  • Emerging research explores DBS for dystonia, Tourette Syndrome (TS), and epilepsy.

Purpose of the Study:

  • To review the efficacy of DBS in Parkinson's disease and essential tremor.
  • To discuss the potential applications of DBS in other neurological conditions.
  • To evaluate the long-term outcomes and safety profile of DBS.

Main Methods:

  • Review of short- and intermediate-term outcome studies on DBS for PD and ET.
  • Analysis of long-term follow-up data.

Related Experiment Videos

  • Assessment of adverse effects and complications associated with DBS.

    • Main Results:

    • DBS provides significant motor symptom relief in PD and ET patients.
    • Sustained benefits are observed in long-term follow-up studies.
    • DBS improves daily living activities, reduces drug-induced dyskinesia, and enhances quality of life.
    • Many patients can reduce antiparkinsonian medication dosages.
    • Adverse effects are typically transient, though device-related complications can occur.

    Conclusions:

    • DBS is a highly effective treatment for medically intractable PD and ET.
    • It is considered the surgical procedure of choice for carefully selected patients.
    • DBS shows promise for treating dystonia, Tourette Syndrome, and epilepsy.