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Expression of semaphorin 6D in gastric carcinoma and its significance
Xiang-Yang Zhao1, Lin Chen, Qian Xu
1Department of General Surgery, General Hospital of Chinese PLA, 28 Fuxing Road, Beijing 100853, China.
Aim:
To investigate the protein and mRNA expression of semaphorin 6D in gastric carcinoma and its significance.
Methods:
The protein and mRNA expression of semaphorin 6D was detected by semi-quantitative reverse transcription PCR and Western blotting respectively in 30 cases of gastric carcinoma and normal gastric mucosa.
Results:
The protein and mRNA expression of semaphorin 6D in gastric carcinoma was significantly higher than that in normal gastric mucosa (0.24 +/- 0.06 vs 0.19 +/- 0.07, 0.26 +/- 0.09 vs 0.20 +/- 0.10, P < 0.05).
Conclusion:
Semaphorin 6D may play an important role in the occurrence and development of gastric carcinoma, and is related to tumor angiogenesis.
