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Updated: Jul 18, 2026
09:50
Detection of Tissue-resident Bacteria in Bladder Biopsies by 16S rRNA Fluorescence In Situ Hybridization
Published on: October 18, 2019
[Fluorescence in situ hybridization in diagnosis of urinary bladder cancer]
Arkhiv Patologii
|December 6, 2006
Abstract:
The paper presents preliminary results of a study of the diagnosis of urinary bladder cancer by fluorescence in situ hybridization (FISH). Specific chromosomal aberrations are shown to be detectable in both proper tumor tissue and urine from patients with urinary bladder cancer; and the pattern of these changes coincides. FISH may identify cells with genetic disorders in urine long before the clinical symptoms of a recurrence occur.
Related Concept Videos
02:07FISH - Fluorescent In-situ Hybridization
Fluorescence in situ hybridization, or FISH, was developed in the early 1980s and has quickly become one of the most widely used techniques in cytogenetics. Labeled probes are used to bind complementary DNA or RNA sequences on a chromosome or in a region within a cell. Earlier, the probes could only be obtained by cloning or reverse transcription of a DNA template. Currently, the probe oligonucleotides can be synthesized synthetically. Additionally, with the advancement of optical techniques,...
02:31In-situ Hybridization
In situ hybridization (ISH) is a technique used to detect and localize specific DNA or RNA molecules in cells, tissue, or tissue sections using a labeled probe. The technique was first used in 1969 for the investigation of nucleic acids. It is currently an essential tool in scientific research and clinical settings, especially for diagnostic purposes.
Types of probes and labels
A probe is a complementary strand of DNA or RNA that binds to corresponding nucleotide sequences in a cell. Many...
Types of probes and labels
A probe is a complementary strand of DNA or RNA that binds to corresponding nucleotide sequences in a cell. Many...