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No incremental clinical information of NT Pro BNP at peak exercise over resting levels in patients with impaired left

M S Kallistratos, A Dritsas, I D Laoutaris

    International Journal of Cardiology
    |December 6, 2006
    PubMed

    Insights

    Peak exercise NT-proBNP levels do not offer additional information beyond resting levels for heart failure patients. Resting levels of NT-proBNP (N-terminal pro-B-type natriuretic peptide) are sufficient for clinical assessment.

    Area of Science:

    • Cardiology
    • Biomarkers
    • Heart Failure Research

    Background:

    • Increasing interest in utilizing NT-proBNP (N-terminal pro-B-type natriuretic peptide) levels during peak exercise.
    • Limited research on the superiority of exercise NT-proBNP over resting levels in heart failure.
    • Inadequate understanding of factors influencing NT-proBNP increase during exercise in heart failure.

    Purpose of the Study:

    • To investigate whether NT-proBNP levels at peak exercise provide incremental clinical information compared to resting levels in patients with heart failure.
    • To explore factors associated with elevated NT-proBNP during exercise in this population.

    Main Methods:

    • Study included 65 patients (51 males, 14 females) with impaired left ventricular function.
    • Mean left ventricular ejection fraction (LVEF) was 35+/-9%.
    • Blood samples were analyzed for NT-proBNP levels at rest and peak exercise.

    Main Results:

    • NT-proBNP plasma levels measured at peak exercise did not yield additional clinical information compared to resting levels.
    • Resting NT-proBNP levels alone were found to be sufficient for providing adequate clinical information in heart failure patients.

    Conclusions:

    • Exercise NT-proBNP testing offers no incremental value over resting measurements in patients with heart failure.
    • Baseline NT-proBNP levels are a reliable and sufficient biomarker for clinical assessment in heart failure.

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