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Valerian for sleep: a systematic review and meta-analysis
Stephen Bent1, Amy Padula, Dan Moore
1Osher Center for Integrative Medicine, University of California, San Francisco, CA 94121, USA. stephen.bent@ucsf.edu
The American Journal of Medicine
|December 6, 2006
Summary
Valerian root extract may improve sleep quality for adults experiencing insomnia. This review of clinical trials suggests a potential benefit without significant side effects, though more research is needed.
Area of Science:
- Herbal medicine
- Sleep science
- Clinical research
Background:
- Insomnia affects one-third of adults, leading to absenteeism and disability.
- Valerian (Valeriana officinalis) root extracts are commonly used for sleep induction and quality enhancement.
Purpose of the Study:
- To systematically review randomized, placebo-controlled trials on valerian for improving sleep quality.
- To assess the efficacy and safety of valerian as a sleep aid.
Main Methods:
- Conducted an extensive literature search to identify eligible randomized, placebo-controlled trials.
- Included 16 studies with a total of 1093 patients.
- Analyzed data focusing on sleep quality outcomes and identified methodological limitations.
Main Results:
- Six studies reported a statistically significant benefit in sleep quality (RR 1.8, 95% CI 1.2-2.9).
- Evidence of publication bias was noted in the summary measure of sleep quality.
- Variability in valerian doses, preparations, and treatment durations across studies was observed.
Conclusions:
- Available evidence suggests valerian may improve sleep quality with a low risk of side effects.
- Further high-quality studies are recommended to evaluate standardized valerian preparations at various doses.
- Future research should incorporate standard measures for sleep quality and safety assessments.
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