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Updated: Jul 18, 2026
Induction of Alloantigen-specific Anergy in Human Peripheral Blood Mononuclear Cells by Alloantigen Stimulation with Co-stimulatory Signal Blockade
Published on: March 14, 2011
[Clinical study on pulmonary complications after allogeneic peripheral blood stem cell transplantation]
Yi-zhuo Zhang1, Wan-ming Da, Bo-Long Zhang
1Department of Hematology, PLA General Hospital, Beijing 100853, China.
Objective:
To explore the incidence, pathogenesis, risk factors and effective treatment of pulmonary complications after allogeneic peripheral blood stem cell transplantation (allo-PBSCT).
Methods:
Pulmonary complications in 70 patients received allo-PBSCT were analyzed.
Results:
Thirty one episodes were observed in 26 patients. Among them episodes were infectious complications, including bacteria pneumonia, pulmonary fungus disease, CMV interstitial pneumonia and tuberculosis, some cases were caused by two pathogens, and 11 episodes were noninfectious complications, including late-onset noninfectious pulmonary complications (LONIPCs) (n=9), pulmonary edema (n=1) and interstitial pneumonia (n=1). The overall mortality was 12.9%. Graft-versus-host disease (GVHD) prophylaxis without MTX, severe acute GVHD and extensive chronic GVHD were high risk factors for pulmonary complications and advanced disease at transplantation, extensive chronic GVHD were significantly associated with the incidence of LONIPCs.
Conclusion:
Pulmonary disease is the main complication occurred in patients undergoing allo-PBSCT. It is of greatly importance to treat pathogens specifically and diagnose LONIPCs in its early stage.
Insights
Pulmonary complications are common after allogeneic peripheral blood stem cell transplantation (allo-PBSCT). Early diagnosis and specific treatment of infections and late-onset noninfectious pulmonary complications (LONIPCs) are crucial.
Area of Science:
- Hematology
- Transplantation Medicine
- Pulmonology
Context:
- Allogeneic peripheral blood stem cell transplantation (allo-PBSCT) is a life-saving procedure.
- Pulmonary complications represent a significant cause of morbidity and mortality post-transplant.
Purpose:
- To investigate the incidence, pathogenesis, risk factors, and treatment of pulmonary complications following allo-PBSCT.
- To identify key factors associated with infectious and noninfectious pulmonary sequelae.
Summary:
- Thirty-one pulmonary complication episodes occurred in 26 of 70 patients undergoing allo-PBSCT.
- Infectious causes included bacterial pneumonia, fungal disease, CMV pneumonia, and tuberculosis. Noninfectious complications included late-onset noninfectious pulmonary complications (LONIPCs).
- Graft-versus-host disease (GVHD) prophylaxis without MTX, severe acute GVHD, and extensive chronic GVHD were risk factors for pulmonary complications, while extensive chronic GVHD was linked to LONIPCs.
Impact:
- Pulmonary disease is a primary complication after allo-PBSCT.
- Targeted pathogen treatment and early LONIPC diagnosis are essential for improved patient outcomes.
- Understanding risk factors can guide preventative strategies and clinical management.
