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Updated: Jul 18, 2026

Intracellular Phosphoflow Cytometry of Acute Myeloid Leukemia Patient-Derived Xenotransplants
Published on: June 6, 2025
[Study of mutation and single nucleotide polymorphism of PDGFRbeta and SHIP gene in acute myeloid leukemia]
Su-jiang Zhang1, Jian-yong Li, Jing-yi Shi
1Department of Hematology, the First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, China.
Objective:
To investigate the significance of mutation and single nucleotide polymorphism (SNP) of class III receptor tyrosine kinases such as PDGFRbeta and SHIP in acute myeloid leukemia (AML) patients.
Methods:
Screening of the mutation and SNP of PDGFRbeta and SHIP by genomic PCR, RT-PCR, directly sequencing and Mass-ARRAY system was carried out in 273 AML patients.
Results:
The mutations of PDGFRbeta R685C and SHIP Q1153L were detected for the first time in AML patients. The positivity ratio was 0.73% and 0.36% respectively.
Conclusion:
The mutations of PDGFRbeta R685C and SHIP Q1153L may contribute to leukemogenesis of AML.

