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Updated: Jul 18, 2026

Self-Assembly of Gamma-Modified Peptide Nucleic Acids into Complex Nanostructures in Organic Solvent Mixtures
Published on: June 26, 2020
Synthesis of peptide ribonucleic acid consisting of D- and L-gamma-glutamic acid as a backbone structure
Takehiko Wada1, Yusuke Hashimoto, Hirofumi Sato
1PRESTO, JST, Yamada-oka, Suita 565-0871, Japan.
Abstract:
A novel nucleic acid model using peptide ribonucleic acid (PRNA), which contains 5-amino-5-deoxyribonucleoside as a recognition site for nucleic acids and consists D-glutamic acid (D-PRNA) instead of L-glutamic acid (L-PRNA) as a backbone structure, has been designed and synthesized. Difference between D-PRNA and L-PRNA oligomers was elucidated on the basis of the effects of chirality of gamma-glutamic acid backbone upon structure elucidated by CD spectra.
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