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Preparation and Characterization of Nanoliposomes for the Entrapment of Bioactive Hydrophilic Globular Proteins
Published on: August 31, 2019
Morphological change of a liposome induced by an oligonucleotide tagged with lipophilic unit
Koh-ichiroh Shohda1, Tadashi Sugawara
1Department of Basic Science, Graduate School of Arts and Sciences, The University of Tokyo, Komaba, Meguro-ku, Tokyo 153-8902, Japan.
Abstract:
We synthesized a conjugate molecule which consisted of DNA, cholesterol, and poly(ethylene glycol) as a spacer. When DNA duplex containing this simple conjugate was added to a liposome solution, interestingly, a pearling transformation of the liposome was observed. Such a morphological change of the liposome is required in the study of synthesizing an artificial cellular life, because the cell division is one of the essential characteristic of the life system.

