Chemical synthesis of RNA including 5-taurinomethyluridine
Toshihiko Ogata1, Takeshi Wada
1Department of Medical Genome Sciences, Graduate School of Frontier Sciences, The Universitiy of Tokyo, Bioscience Bldg 702, Kashiwa, Chiba 277-8562, Japan.
Nucleic Acids Symposium Series (2004)
|December 8, 2006
Abstract:
Recently, a novel base-modified uridine derivative, 5-taurinomethyluridine (taum(5)U) was discovered from bovine and human mitochondrial tRNAs, and this modified ribonucleoside was found to existed at the first position of the anti-codon. We report efficient reactions for the synthesis of RNA oligomers including this base-modified ribonucleotide.
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