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Anti-SARS-CoV activity of nucleoside analogs having 6-chloropurine as a nucleobase
Masahiro Ikejiri1, Masayuki Saijo, Shigeru Morikawa
1Faculty of Pharmaceutical Sciences at Kagawa Campus, Tokushima Bunri University, 1314-1 Shido, Sanuki, Kagawa 769-2193, Japan.
Abstract:
Nucleoside analogs that have 6-chloropurine as a nucleobase were synthesized and evaluated to develop novel anti-SARS-CoV agents. Two compounds among them showed promising activity that was comparable to mizoribine and ribavirin. Moreover, one of the compounds showed a structurally unique property.
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