Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Multiple circuits relaying primate parallel visual pathways to the middle temporal area.

Jonathan J Nassi1, Edward M Callaway

  • 1Systems Neurobiology Laboratories, The Salk Institute for Biological Studies, La Jolla, California 92037, USA.

The Journal of Neuroscience : the Official Journal of the Society for Neuroscience
|December 8, 2006
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

A disinhibitory basal forebrain-to-cortex projection supports sustained attention.

Cell·2026
Same author

Protocol for mapping neural circuit connectivity with START: Single transcriptome assisted rabies tracing.

STAR protocols·2026
Same author

Genome-Wide Translatome Analysis Following Low-Dose Ketamine to Reveal Novel Targets for Antidepressant Treatment.

Synapse (New York, N.Y.)·2025
Same author

Asymmetric cortical projections to striatal direct and indirect pathways distinctly control actions.

eLife·2025
Same author

Microendoscopic calcium imaging in motor cortices of macaques during rest and movement.

iScience·2025
Same author

Complementary Organization of Mouse Driver and Modulator Cortico-thalamo-cortical Circuits.

The Journal of neuroscience : the official journal of the Society for Neuroscience·2025
Same journal

Endogenous peptide derived from c-Cbl-associated protein counteracts its inhibitory effect on enteric neural crest cell colonization in Hirschsprung disease.

The Journal of neuroscience : the official journal of the Society for Neuroscience·2026
Same journal

Drowsiness alters the neural dynamics but not the core computations of multisensory integration.

The Journal of neuroscience : the official journal of the Society for Neuroscience·2026
Same journal

A Matter of Parameters: Tailored Transcranial Focused Ultrasound Enhances Cortico-Thalamo-Cortical Circuit Resonance.

The Journal of neuroscience : the official journal of the Society for Neuroscience·2026
Same journal

Proactive visual and motor prioritization differentially scale with cue reliability.

The Journal of neuroscience : the official journal of the Society for Neuroscience·2026
Same journal

Erratum: Yao et al., "Estrogen Regulates Bcl-w and Bim Expression: Role in Protection against β-Amyloid Peptide-Induced Neuronal Death".

The Journal of neuroscience : the official journal of the Society for Neuroscience·2026
Same journal

Erratum: L'Episcopo et al., "Plasticity of Subventricular Zone Neuroprogenitors in MPTP (1-Methyl-4-Phenyl-1,2,3,6-Tetrahydropyridine) Mouse Model of Parkinson's Disease Involves Cross Talk between Inflammatory and Wnt/β-Catenin Signaling Pathways: Functional Consequences for Neuroprotection and Repair".

The Journal of neuroscience : the official journal of the Society for Neuroscience·2026
See all related articles

The magnocellular (M) and parvocellular (P) visual pathways exhibit significant M and P convergence in the middle temporal area (MT) via multiple routes from V1. This suggests specialized information processing in the dorsal stream.

Area of Science:

  • Neuroscience
  • Visual System Processing
  • Primate Visual Pathways

Background:

  • The primate visual system comprises distinct magnocellular (M), parvocellular (P), and koniocellular (K) pathways.
  • These pathways maintain anatomical segregation through the lateral geniculate nucleus to primary visual cortex (V1).
  • Recent findings suggest less compartmentalization of M and P pathway outputs from V1, complicating analysis of downstream contributions.

Purpose of the Study:

  • To investigate the contributions of M and P pathways to visual areas MT, V3, and V2 in macaque monkeys.
  • To elucidate the specific routes and convergence patterns of M and P inputs to these areas beyond V1.

Main Methods:

  • Utilized rabies virus as a retrograde transsynaptic tracer.
  • Studied the macaque monkey visual system, focusing on pathways from V1 to MT, V3, and V2.

Related Experiment Videos

Main Results:

  • Disynaptic inputs to dorsal stream area MT from V1's layer 4C are primarily M pathway-driven.
  • MT receives substantial P pathway input within three additional synapses, not predominantly via V3.
  • V3 also shows predominantly M pathway disynaptic input from V1.
  • V2 receives more balanced M and P disynaptic inputs, potentially contributing to MT convergence.

Conclusions:

  • Evidence for multiple pathways from V1 to MT with varying M and P pathway convergence.
  • These distinct pathways likely transmit functionally specialized information to MT and the dorsal stream for visual processing.