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'The heart less bounding': treating angina pectoris.

¹Bute Medical School, University of St Andrews, St Andrews, Scotland. arb3@st-andrews.ac.uk

The Journal of the Royal College of Physicians of Edinburgh

|December 13, 2006

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Nitric oxide, identified in 1987, explains how nitrates treat angina. Once overlooked, sodium nitrite is regaining therapeutic interest, potentially due to nitrite impurities in saltpetre.

Area of Science:

Pharmacology and cardiovascular medicine.
Nitric oxide signaling pathways.

Background:

Nitrate-based drugs, like amyl nitrite and glyceryl trinitrate, have a long history in angina treatment.
The mechanism of action for these vasodilators was elucidated following the identification of nitric oxide (NO) in 1987.

Observation:

Sodium nitrite was an early inclusion in nitrate therapies but was largely abandoned.
Recent research indicates a resurgence of interest in the therapeutic applications of sodium nitrite.

Findings:

The vasodilatory effects of nitrates are primarily mediated by nitric oxide.
The revival of interest in sodium nitrite may be linked to its potential as a source of NO.

Implications:

Understanding NO pathways enhances the therapeutic use of existing and novel nitrate drugs.

Related Experiment Videos

Re-evaluation of sodium nitrite could lead to new treatment strategies for cardiovascular conditions like angina.