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Contractions of Human-iPSC-derived Cardiomyocyte Syncytia Measured with a Ca-sensitive Fluorescent Dye in Temperature-controlled 384-well Plates
Published on: October 18, 2018
[Cardiomyocyte culture as a highly sensitive system for testing pharmacological activity of specific bradycardic
Eksperimental'Naia I Klinicheskaia Farmakologiia
|December 13, 2006
Abstract:
Two antiarrhythmic agents were studied: verapamil and bradizole, a new bradycardic drug. It was found that both drugs exhibit a dose-dependent negative chronotropic effect on the culture of contractile cardiomyocytes of newborn rats. Bradizole showed more pronounced bradycardic properties than verapamil.
