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Updated: Jul 18, 2026
04:14
In vivo Characterization of Endocrine Disrupting Chemical Effects via Thyroid Hormone Action Indicator Mouse
Published on: October 6, 2023
Thyroid receptor ligands. 6. A high affinity "direct antagonist" selective for the thyroid hormone receptor
Konrad Koehler1, Sandra Gordon, Peter Brandt
1Karo Bio AB, Novum, Huddinge SE-141 57, Sweden.
Journal of Medicinal Chemistry
|December 13, 2006
Abstract:
A new high-affinity thyroid hormone antagonist 6 with druglike properties was designed and synthesized. The compound behaved as an antagonist in a cell transactivation assay, and in a first in vivo experiment in rats.
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