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Related Experiment Videos

ATP and pain.

Sara G Hamilton1

  • 1Neuroscience Research Centre, Guy's King's and Thomas' School of Biomedical Sciences, London, SE1 1UL, United Kingdom. sara.hamilton@kcl.ac.uk

Pain Practice : the Official Journal of World Institute of Pain
|December 13, 2006
PubMed
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Adenosine triphosphate (ATP) plays a role in pain signaling. Blocking ATP receptors, specifically P2X ion channels, may offer new strategies for pain relief.

Area of Science:

  • Neuroscience
  • Pharmacology
  • Pain Research

Background:

  • Adenosine triphosphate (ATP) has long been known to produce pain.
  • Recent discovery of ATP-gated ion channels (P2X family) on pain-sensing neurons has renewed interest in ATP's role.
  • ATP's involvement in physiological and pathophysiological processes is under investigation.

Purpose of the Study:

  • To evaluate the evidence supporting ATP receptors as novel analgesic targets.
  • To assess the hypothesis that ATP mediates pain.
  • To review the potential of blocking ATP receptors for pain management.

Main Methods:

  • Review of existing literature on ATP receptors (P2X family) distribution.
  • Examination of conditions for ATP release.

Related Experiment Videos

  • Analysis of evidence for ATP-induced pain in humans and pain behaviors in animals.
  • Assessment of analgesic effects from pharmacological or molecular blockade of ATP receptors.

    • Main Results:

    • ATP receptors, particularly P2X channels, are expressed by nociceptive neurons.
    • Evidence suggests ATP is released under conditions relevant to pain.
    • ATP can initiate pain and pain-related behaviors.
    • Pharmacological or molecular blocking of ATP receptors shows analgesic potential.

    Conclusions:

    • ATP acts as a significant mediator of pain.
    • ATP receptors represent promising targets for developing new analgesics.
    • Targeting P2X ion channels could lead to effective pain management strategies.