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Partial Sciatic Nerve Ligation: A Mouse Model of Chronic Neuropathic Pain to Study the Antinociceptive Effect of Novel Therapies
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Invasive Spinal Neuromodulation for Chronic Pain in Pediatric Patients: A Scoping Review.

Puneet Gupta1, Vibha Sastri2, Antony Sharobim1

  • 1Department of Anesthesiology & Critical Care Medicine, The George Washington University School of Medicine and Health Sciences, Washington DC, USA.

Pain Practice : the Official Journal of World Institute of Pain
|June 26, 2026
PubMed
Summary

Spinal neuromodulation, particularly spinal cord stimulation (SCS), shows promise for pediatric chronic pain, especially complex regional pain syndrome (CRPS) and erythromelalgia. More research is needed to confirm long-term safety and effectiveness in children.

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Area of Science:

  • Neurology
  • Pain Management
  • Pediatric Medicine

Background:

  • Chronic pain significantly impacts pediatric patients' quality of life.
  • Spinal neuromodulation (SCS, DRG-S) is effective in adults but understudied in children.

Conclusions:

  • Spinal neuromodulation, mainly SCS, is a promising adjunctive therapy for pediatric refractory pain.
  • Evidence is limited to small studies; high-quality prospective research is needed.
  • Further studies should focus on long-term safety, efficacy, and patient selection.