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Updated: Jul 18, 2026

Assessment of DNA Double Strand Break Repair Activity Using High-throughput and Quantitative Luminescence-Based Reporter Assays
Published on: June 14, 2024
First attempts at prediction of DNA strand-break yields using nanodosimetric data
G Garty1, R Schulte, S Shchemelinin
1Department of Particle Physics, Weizmann Institute of Science, Rehovot, Israel. gyg2101@columbia.edu
Abstract:
We present the first results of our attempts to correlate yields of ionisation clusters in a gas model of DNA and corresponding double-strand break (DSB) yields in irradiated plasmids, using a simple statistical model of DNA lesion formation. Based on the same statistical model, we also provide a comparison of simulated nanodosimetric data for electrons and published DSB yields obtained with the PARTRAC code.
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