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Updated: Jul 18, 2026
Establishment of a Simple and Effective Rat Model for Intraoperative Parathyroid Gland Imaging
Published on: August 17, 2022
[Usefulness of intraoperative PTH measurement in primary and secondary hyperparathyroidism: experience with 109
Monique Nakayama Ohe1, Rodrigo Oliveira Santos, Ilda Shizue Kunii
1Escola Paulista de Medicina, Universidade Federal de São Paulo, São Paulo, SP. moniqueohe@uol.com.br
Introduction:
Intraoperative parathyroid hormone measurement (IO-PTH) was first described in 1988 and it's potentially useful in predicting cure after parathyroidectomy. The aim of this study was to evaluate IO-PTH decay profile and the utility of this procedure in predicting cure in primary (PHH) and secondary (SHH) hyperparathyroidism due to renal disease.
Patients And Methods:
109 patients were evaluated from 06/2000 to 12/2004. 33 had PHH and 76 SHH (52 in dialysis, 24 with renal graft). IO-PTH was measured at times 0 (before resection), 10, 20 minutes after parathyroidectomy using immunometric assay (Elecsys-PTH/Immunoassay-Roche). Time necessary to perform assay: 10 minutes.
Results:
HPP patients: IO-PTH average decrease 79.2% from basal levels after 10 minutes. HPS: IO-PTH average decrease 85.8% and 87.6% after 10 minutes in dialysis and renal graft patients respectively. All patients were cured, except 2 (1 PHH, 1 SHH), because of a double adenoma and ectopic (mediastinal) parathyroid respectively. Failure in IO-PTH decrease was observed in both.
Conclusion:
IO-PTH measurement is useful in improving surgical success rates in PHH and SHH.
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